Toxicity Test of Sentul Fruit (Sandoricum koetjape) Peel Extract on Mice

Background : Sentul fruit peel extract has an antibacterial activity since it contains saponin, flavonoid, phenol, and tannin. Hence, can be utilized in oral infection treatment. The safety level of herbal medicines needs to studied by using a toxicity test. study aims discover the extract. Subjects Method was conducted laboratory Faculty Food Technology Warmadewa University Medicine Health Sciences University. independent variables were various doses administered orally. dependent variable acute test mice used experimental design that observed qualitatively quantitatively. animals 25 male white (Mus musculus) divided into 5 groups. Data collected based on results examinations from subsequently analyzed descriptively. Results Based LD50 Toxicity Test Mice, samples did not cause toxic symptoms form decreased heart activity, convulsions, movement slow breathing. administration categorized as non-toxic because do experience abnormal there no death after gavage method at all for 14 days, thus safe use medicinal ingredient. Conclusion is occurs. Keywords peel, extraction, infection, mice, Correspondence I Nyoman Wirata, Polytechnic Ministry Denpasar. Jl. Sanitasi No.1, Sidakarya, South Denpasar, Denpasar City, Bali 80224. Email: [email protected]. Mobile: 08123649998. Indonesian Journal (2023), 08(01): 114-120 https://doi.org/10.26911/theijmed.2023.08.01.11